This course provides a comprehensive introduction to molecular biology, focusing on the structure, transmission, expression, and regulation of genetic information. It aims to give students a solid theoretical and methodological foundation to understand how genetic information is stored, maintained, expressed, and modified at the molecular level.
The course begins with an in-depth study of DNA as the molecular support of genetic information, including its structure, physicochemical properties, alternative conformations, and biological implications. Particular emphasis is placed on the organization of prokaryotic and eukaryotic genomes and their functional significance.
Students will then explore genetic mutations and mutagenesis, covering natural and induced mutations, their mechanisms, biological consequences, and their role in evolution, disease, and genetic variability. Methods for genotypic diagnosis and mutation detection are also introduced.
The course further addresses the transmission and conservation of genetic information, with detailed analysis of DNA replication, regulation of replication, and DNA repair mechanisms. Restriction–modification systems and restriction mapping are presented as fundamental tools in molecular genetics and biotechnology.
- المعلم: Abdelkrim AROUSSI